Development of nano- / microfibrous and non-fibrous composite materials suitable for use in tissue engineering (replacements of cartilage, bone, blood vessels, nerve and skin tissues, glaucoma therapy)
Testing of cytotoxicity of materials according to standard
Static and dynamic biological in-vitro testing of surface and three-dimensional structures
Development and testing of drug delivery systems
Research and development of new spinning principles and technologies leading to the production of nanofibers and nanofibrous composite materials,
Development and production of textile composite materials for health care (wound covers, bandages, prevention of complications in colorectal surgery).
Specialization of the laboratory
Research and development of biodegradable and non-degradable tissue engineering carriers (intelligent wound covers, vascular replacements, bone and cartilage replacements, glaucoma implants, adhesion prevention materials and for strengthening surgical anastomoses),
focus mainly on nanofiber and composite materials, foams, 3D structures and linear formations,
For the materials produced, morphological analysis is performed using optical (including fluorescent) and electron microscopy and EDS analysis.
Materials are tested in-vitro using selected cell cultures (3T3, NHDF, HUVEC, MG63, HEKa) for cytotoxicity, cell adhesion, viability and cell proliferation rate (MTT assay, CCK-8 assay, fluorescence microscopy and scanning electron microscopy).
Institute of Experimental Medicine
2nd Faculty of Medicine
Third Faculty of Medicine
Liberec Regional Hospital
Biomedical Center of the Faculty of Medicine of Charles University in Pilsen